
Multiplmiyelom 'da umut vaat eden yeni tedavilere ulaşmak için lütfen tıklayınız.
2005
2006
2007
2011
2013
haematologica the hematology journal Induction Therapy in Multiple Myeloma
European Myeloma Network guidelines for the management of multiple myeloma-related complications.
2014
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.
Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BG, Miguel JF. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014 Nov;15(12):e538-48. doi: 10.1016/S1470-2045(14)70442-5. Epub 2014 Oct 26. Review.PMID: 25439696
San-Miguel JF, Hungria VT, Yoon SS, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, Corradini P, Chuncharunee S, Lee JJ, Schlossman RL, Shelekhova T, Yong K, Tan D, Numbenjapon T, Cavenagh JD, Hou J, LeBlanc R, Nahi H, Qiu L, Salwender H, Pulini S, Moreau P, Warzocha K, White D, Bladé J, Chen W, de la Rubia J, Gimsing P, Lonial S, Kaufman JL, Ocio EM, Veskovski L, Sohn SK, Wang MC, Lee JH, Einsele H, Sopala M, Corrado C, Bengoudifa BR, Binlich F, Richardson PG. Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. Lancet Oncol. 2014 Oct;15(11):1195-206. doi: 10.1016/S1470-2045(14)70440-1. Epub 2014 Sep 18. Erratum in: Lancet Oncol. 2015 Jan;16(1):e6. PMID:25242045
Engelhardt M, Terpos E, Kleber M, Gay F, Wäsch R, Morgan G, Cavo M, van de Donk N, Beilhack A, Bruno B, Johnsen HE, Hajek R, Driessen C, Ludwig H, Beksac M, Boccadoro M, Straka C, Brighen S, Gramatzki M, Larocca A, Lokhorst H, Magarotto V, Morabito F, Dimopoulos MA, Einsele H, Sonneveld P, Palumbo A; European Myeloma Network. European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma. Haematologica. 2014 Feb; 99(2):232-42. doi: 10.3324/haematol.2013.099358.PMID:24497560
2015
Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma.
· Scheid C, Reece D, Beksac M, Spencer A, Callander N, Sonneveld P, Kalimi G, Cai C, Shi M, Scott JW, Stewart AK. Phase 2 study of dovitinib in patients with relapsed or refractory multiple myeloma with or without t(4;14) translocation. Eur J Haematol. 2015 Oct;95(4):316-24. doi: 10.1111/ejh.12491. Epub 2015 Jan 22.PMID:25402977
Richardson PG, Laubach JP, Lonial S, Moreau P, Yoon SS, Hungria VT, Dimopoulos MA, Beksac M, Alsina M, San-Miguel JF. Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma. ExpertRevAnticancerTher.2015;15(7):737-48. doi: 10.1586/14737140.2015.1047770. Epub 2015 Jun 7. Erratum in: Expert Rev Anticancer Ther. 2015;15(9):1121 . PMID:26051506
Lonial S, Dimopoulos M, Palumbo A, White D, Grosicki S, Spicka I, Walter-Croneck A, Moreau P, Mateos MV, Magen H, Belch A, Reece D, Beksac M, Spencer A, Oakervee H, Orlowski RZ, Taniwaki M, Röllig C, Einsele H, Wu KL, Singhal A, San-Miguel J, Matsumoto M, Katz J, Bleickardt E, Poulart V, Anderson KC, Richardson P; ELOQUENT-2 Investigators. Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma. N Engl J Med. 2015 Aug 13;373(7):621-31. doi: 10.1056/NEJMoa1505654. Epub 2015 Jun 2.PMID:26035255
Iacobelli S, de Wreede LC, Schönland S, Björkstrand B, Hegenbart U, Gruber A, Greinix H, Volin L, Narni F, Carella AM, Beksac M, Bosi A, Milone G, Corradini P, Friberg K, van Biezen A, Goldschmidt H, de Witte T, Morris C, Niederwieser D, Garderet L, Kröger N, Gahrton G; EBMT CMWP, Plasma Cell Disorders Subcommittee. Impact of CR before and after allogeneic and autologous transplantation in multiple myeloma: results from the EBMT NMAM2000 prospective trial. Bone Marrow Transplant. 2015 Apr;50(4):505-10. doi: 10.1038/bmt.2014.310. Epub 2015 Jan 26.PMID:25621805
Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment Paul G. Richardson , Vânia T. M. Hungria , Sung-Soo Yoon , Meral Beksac , Meletios Athanasios Dimopoulos
, Ashraf Elghandour , Wieslaw W. Jedrzejczak , Andreas Guenther , Thanyaphong Na Nakorn , Noppadol Siritanaratkul , Robert L. Schlossman , Jian Hou , Philippe Moreau , Sagar Lonial , Jae Hoon Lee , Hermann Einsele , Monika Sopala , Bourras-Rezki Bengoudifa , Claudia Corrado , Florence Binlich , and Jesús F. San-Miguel 18 Received 2015 Sep 8 127:713-721; Accepted 2015 Nov 20
2016
Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma
Phase 2 study of tabalumab, a human anti-B-cell activating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma
Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma Antonio Palumbo, M.D., Asher Chanan‑Khan, M.D., Katja Weisel, M.D., Ajay K. Nooka, M.D., Tamas Masszi, M.D., Meral Beksac, M.D., Ivan Spicka, M.D., Vania Hungria, M.D., Markus Munder, M.D., Maria V. Mateos, M.D., Tomer M. Mark, M.D., Ming Qi, M.D., Jordan Schecter, M.D., Himal Amin, B.S., Xiang Qin, M.S., William Deraedt, Ph.D., Tahamtan Ahmadi, M.D., Andrew Spencer, M.D., and Pieter Sonneveld, M.D., for the CASTOR Investigators NEngl J Med 2016;375:754-66. DOI: 10.1056/NEJMoa1606038
Beksac M, Gragert L, Fingerson S, Maiers M, Zhang MJ, Albrecht M, Zhong X, Cozen W, Dispenzieri A, Lonial S, Hari P. HLA polymorphism and risk of multiple myeloma. Leukemia. 2016 Jul 27. Leukemia volume 30, pages 2260–2264 doi: 10.1038/leu.2016.199.
Palumbo A, Chanan-Khan A, Weisel K, Nooka AK, Masszi T, Beksac M, Spicka I,Hungria V, Munder M, Mateos MV, Mark TM, Qi M, Schecter J, Amin H, Qin X, Deraedt W, Ahmadi T, Spencer A, Sonneveld P; CASTOR Investigators.. Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma. N Engl J Med. 2016 Aug 25;375(8):754-66. . DOI: 10.1056/NEJMoa1606038
San-Miguel JF, Hungria VT, Yoon SS, Beksac M, Dimopoulos MA, Elghandour A,Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, Schlossman RL, Hou J,Moreau P, Lonial S, Lee JH, Einsele H, Sopala M, Bengoudifa BR, Binlich F, Richardson PG. Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial. Lancet Haematol. 2016 Oct 14. pii: S2352-3026(16)30147-8. doi:10.1016/S2352-3026(16)30147-8. [Epub ahead of print] PubMed PMID: 27751707.
Raje NS, Moreau P, Terpos E, Benboubker L, Grząśko N, Holstein SA, Oriol A, Huang SY, Beksac M, Kuliczkowski K, Tai DF, Wooldridge JE, Conti I, Kaiser CJ,Nguyen TS, Cronier DM, Palumbo A. Phase 2 study of tabalumab, a human anti-B-cellactivating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma. Br J Haematol. 2016 Dec 22. 176, 783–795 doi:10.1111/bjh.14483. [Epub ahead of print] PubMed PMID: 28005265.
Richardson PG, Hungria VT, Yoon SS, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Guenther A, Nakorn TN, Siritanaratkul N, Schlossman RL, Hou J, Moreau P, Lonial S, Lee JH, Einsele H, Sopala M, Bengoudifa BR, Corrado C, Binlich F, San-Miguel JF. Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment. Blood. 2016 Feb 11;127(6):713-21. doi: 10.1182/blood-2015-09-665018. Epub 2015 Dec 2. PMID:26631116
2017
Sezer O, Beksac M, Hajek R, Sucak G ve ark. "Effects of single-agent bortezomib as post-transplant consolidation therapy on multiple myeloma-related bone disease: A randomized phase 2 study.", Br J Haem, 176(5) 783-795. March 2017 doi: 10.1111/bjh.14637. Epub
Dimopoulus MA, Lonial S, White D, Moreau P, Palumbo A, San- Miguel J, Shpilberg O, Anderson K, Grosicki S, Spicka I, Walter-Croneck A, Magen H, Mateos MV, Belch A, Reece D, Beksac M, Bleickardt E, Poulart V, Sheng J, Sy O, Katz J, Singhal A, Richardson P, “Elotuzumab plus lenalidomide/dexamethasone for relapsed or refractory multiple myeloma: ELOQUENT-2 follow-up and post-hoc analyses on progression-free survival and tumour growth.” Br J Haem, 178(6):896-905, September 2017 doi: 10.1111/bjh.14787. Epub 2017 Jul 5.
Kumar SK, Dimopoulos MA, Kastritis E, Terpos E, Nahi H, Goldschmidt H, Hillengass J, Leleu X,Beksac M , Alsina M, Oriol A, Cavo M, Ocio EM, Mateos MV, O'Donnell EK, Vij R, Lokhorst HM, van de Donk NWCJ, Min C, Mark T, Turesson I, href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Hansson%20M%5BAuthor%5D&cauthor=true&cauthor_uid=28620163" > Hansson M , Ludwig H, Jagannath S, Delforge M, Kyriakou C, Hari P, Mellqvist U, Usmani SZ, Dytfeld D, Badros AZ , Moreau P, Kim K , Otero PR, Lee JH, Shustik C, Waller D, Chng WJ, Ozaki S, Lee JJ, de la Rubia J, Eom HS, Rosinol L, Lahuerta JJ, Sureda A, Kim JS, Durie BGM, “Natural history of relapsed myeloma, refractory to immunomodulatory drugs and proteasome inhibitors: a multicenter IMWG study.”Leukemia, 31(11):2443-2448, Novenber 2017 DOI: 10.1038/leu.2017.138
2018
Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated Myeloma.
Ludwig H, Delforge M, Facon T, Einsele H, Gay F, Moreau P, Avet-Loiseau H, Boccadoro M, Hajek R, Mohty M, Cavo M, Dimopoulos MA, San-Miguel JF, Terpos E, Zweegman S, Garderet L, Mateos MV, Cook G, Leleu X, Goldschmidt H, Jackson G, Kaiser M, Weisel K, van de Donk NWCJ, Waage A, Beksac M, Mellqvist UH, Engelhardt M, Caers J, Driessen C, Bladé J, Sonneveld P. “ Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.” Leukemia. 2018 Jul;32(7):1542-1560 doi: 10.1038/s41375-018-0040-1
Kumar S, Durie B, Nahi H, Vij R, Dimopoulos MA, Kastritis E, Terpos E, Leleu X, Beksac M, Goldschmidt H, Hillengass J, Su Z, Hutton B, Cameron C, Khan I, Lam A “Propensity score matching analysis to evaluate the comparative effectiveness of daratumumab versus real-world standard of care therapies for patients with heavily pretreated and refractory multiple myeloma”. Leuk Lymphoma. 2018 May 9:1-9. doi: 10.1080/10428194.2018.1459609
Weisel K, Sonneveld P, Spencer A, Beksac M, Rizzo M, Xu Y, Fahrbach K, Gaudig M, Slavcev M, Dearden L, Lam A, “A Comparison of the Efficacy of Immunomodulatory-free Regimens in Relapsed/Refractory Multiple Myeloma: A Network Meta-analysis” Clinical Lymphoma Myeloma and Leukemia,Volume 18, Issue 3, March 2018, Pages 163-173.e6 doi: 10.1016/j.clml.2017.12.011
Insights on Multiple Myeloma Treatment Strategies
2019
Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial